Hyperesthesia: an early manifestation of diabetic polyneuropathy.

Diabetic polyneuropathy is a specific form of peripheral nerve disorder, in which distal nerve axons degenerate insidiously under hyperglycemia of diabetes mellitus. Although all types of peripheral nerve fibers are involved, it is usually sensory dominant with eventual involvement of autonomic and motor nerve fibers. Its manifestation ranges from subclinical changes in nerve conduction to painful and severe motor and autonomic disabilities. Once established, it is irreversible. Early identification is, therefore, of clinical importance.